Thursday, 13 October 2016

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High blood pressure drugs may affect not only blood pressure but also mood disorders including depression and bipolar disorder, finds a new study published in the American Heart Association's journal Hypertension.The Institute of Cardiovascular and Medical Sciences and Institute of Health and Wellbeing at the University of Glasgow in the United Kingdom conducted the research.

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Depression and cardiovascular disease are major contributors to the global burden of disease. A bidirectional relationship is thought to exist between depression and heart disease due to the functional changes that underlie both conditions.
Bipolar disorder is associated with an increased risk of cardiovascular mortality and high blood pressure, whereas major depressive disorder is associated with an increased risk of high blood pressure.

While there is growing evidence that the pathways that high blood pressure drugs target may play a role in the development of mood disorders - suggesting implications in prescribing these drugs in hypertensive patients who may have an underlying mood disorder - results of the link between the two have been inconclusive.
"Mental health is under-recognized in hypertension clinical practice, and the possible impact of antihypertensive drugs on mental health is an area that physicians should be aware of and consider if the treatment of high blood pressure is having a negative impact on their patient's mental health," says study author Dr. Sandosh Padmanabhan, Ph.D., a professor at the Institute of Cardiovascular and Medical Sciences.

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Participants were divided into four groups based on the single high blood pressure drug they had been prescribed: angiotensin antagonists, beta-blockers, calcium channel blockers, or thiazide diuretics. The research also included a control group of 111,936 people who were not exposed to any of these four antihypertensive drug classes during the study period.

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During the 5-year follow-up, researchers documented hospitalization for mood disorders, such as depression or bipolar disorder. The team began examinations after patients had taken antihypertensive medications for 90 days.

Researchers noted 299 hospital admissions among participants, mainly due to major depression at an average of 2.3 years after medication had started.

When comparing the four most common classes of antihypertensive drugs, investigators found that two drugs were associated with an increased risk for mood disorders, while one drug decreased mood disorder risk.

High Blood Pressure Home Remedy

High blood pressure, also known as hypertension, affects nearly a third of all Americans. With hypertension, too much force is exerted on the arteries as blood is pumped through. This results not only in damage to the blood vessels themselves, but to other organs forced to bear the stress.Blood pressure is assessed using two parameters -- the systolic and diastolic pressures -- which measure, respectively, the maximum pressure exerted in the arteries as the heart contracts, and the minimum pressure in those vessels between cardiac contractions. In adults, blood pressure is considered normal if the top number (systolic pressure) is between 90 and 120 and the bottom number (diastolic) is between 60 and 80.

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Diuretics increase urination which reduces sodium and fluid in the body. That can help lower blood pressure because it lowers blood volume. Mild hypertension can sometimes be treated using diuretics alone, although they are more commonly used in combination with other high blood pressure medications. Examples of diuretics include:

Bumetanide (Bumex)
Chlorthalidone (Hygroton)
Chlorothiazide (Diuril)
Ethacrynate (Edecrin)
Furosemide (Lasix)
Hydrochlorothiazide HCTZ (Esidrix, Hydrodiuril, Microzide)
Indapamide (Lozol)
Methyclothiazide (Enduron)
Metolazone (Mykroz, Zaroxolyn)
Torsemide (Demadex)

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One side effect of diuretics is a loss of potassium, which is carried out of the body in urine along with the sodium. Potassium is needed for proper muscular movement and a deficiency of this mineral can result in fatigue, weakness, leg cramps, and even problems with the heart. So often, patients on traditional diuretics will be advised to take their medication with a potassium-rich food, such as orange juice or a banana, or they'll be prescribed a potassium supplement.

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Some diuretics were subsequently developed to address the issue of potassium loss. These blood pressure medications are known as "potassium-sparing" diuretics. They include amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium).

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